This is a preview. Log in through your library . Abstract Programmed cell death–1 (PD-1)–targeted therapies enhance T cell responses and show efficacy in multiple cancers, but the role of ...

New research by scientists at the University of California, San Diego (UCSD) demonstrates through a previously undescribed form of cell auto-signaling, T cells were shown to activate themselves in ...

T-cell-specific surface glycoprotein CD28, also known as TP44, is a single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like) domain. It is a key co-stimulatory ...

Newly discovered mechanism of action of the bacterial superantigen toxins: Superantigens bind to both B7-2 and CD28, the major costimulatory receptors expressed on human immune cells. This binding ...

Scientists find an auto-signaling mechanism driving the T cell anti-tumor response; findings may inspire new cancer therapeutics and biomarkers. When you need a bit of motivation, it often has to come ...