IT is well established that an increase in the intracellular concentration of ionized calcium after excitation in the membrane is the key factor for initiation of contraction of various types of ...

Large-conductance calcium-activated potassium (BK) channels are critical determinants of smooth muscle function by mediating rapid feedback between intracellular calcium levels and membrane potential.

The contractile responses of esophageal smooth muscle (SM) induced by platelet-activating factor (PAF) involve the activation of L-type voltage-dependent calcium channels (L-type VDCCs), ...

Together, these findings suggest that ferulic acid can act as a natural regulator of intestinal motility. By reducing excessive smooth muscle activity, the compound could potentially help calm ...

A research group led by Dr. Keisuke Obara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka from the Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, has ...

Ferulic acid suppresses ileal smooth muscle contraction by inhibiting calcium ion influx through voltage-dependent calcium channels. This action may help prevent or treat excessive intestinal motility ...

Muscle contraction is the tightening, shortening, or lengthening of muscles when you do some activity. It can happen when you hold or pick up something, or when you stretch or exercise with weights.

Actomyosin is a protein complex composed of actin and myosin. It is found in muscle fibers where it plays a role in muscle contraction. Actin is one of the most abundant proteins in eukaryotes. It ...

Evidence from randomized trials suggests that calcium supplements may not significantly reduce fracture risk in ...