Medical Xpress

Loosening chimeric antigen receptor's grip on T-regulatory cells improves function, researchers find

A new paper from MUSC Hollings Cancer Center researchers is helping to reveal the "rules" for engineering chimeric antigen receptor (CAR) Tregs. Tregs, or T-regulatory cells, have shown promise in ...
ascopubs.org

Chimeric Antigen Receptor-T Cells in Colorectal Cancer: Pioneering New Avenues in Solid Tumor Immunotherapy

Phase II Trial of Nivolumab Plus Doxorubicin, Vinblastine, Dacarbazine as Frontline Therapy in Older Adults With Hodgkin Lymphoma Colorectal cancer (CRC) remains a major global health burden, being ...
Nature

Chimeric antigen receptor T-cell therapy is equally effective and safe in older (≥70) and younger patients with multiple myeloma: a multicenter retrospective analysis

In the present study, we sought to evaluate differences in clinical outcomes and toxicity profiles between elderly patients aged 70 years and older and their younger counterparts. By identifying ...
Nature

Chimeric Antigen Receptor T-Cell Therapy in Hematological Malignancies

Chimeric antigen receptor (CAR) T-cell therapy represents a paradigm shift in the treatment of relapsed or refractory haematological cancers by harnessing patients’ own immune cells to target surface ...

China approves CARsgen's CAR-T treatment to treat stomach cancer

SHANGHAI, June 22 (Reuters) - China's drug regulator said on Monday that it has approved a CARsgen Therapeutics treatment to stomach cancer. The injection, also known as satri-cel, was the first CAR T ...

CAR-T cells enhanced with navigation system to penetrate lymph nodes more efficiently

T, has transformed treatment for blood cancers. The immunotherapy involves reprogramming a patient's own immune cells to recognize and attack tumor cells. It offers many patients long-lasting ...
Caixin Global

China Approves World’s First CAR-T Therapy for Solid Tumors

China’s medical regulator has approved a gastric cancer treatment developed by CARsgen Therapeutics, marking the world’s ...
Yicai Global

China’s CARsgen Slides for Second Day on Hefty Price Tag for World’s First Solid Tumor CAR-T Therapy

CARsgen’s share price [HKG: 2171] plunged 11.7 percent to end the day at HKD13.91 (USD1.77) apiece, following a 6.4 percent ...
EurekAlert!

CAR-T cells can arm bystander T cells with CAR molecules via trogocytosis

Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now discovered that CAR molecules can be transferred from the CAR-T cells to ...

Mayo Clinic News Network

My brother was diagnosed with non-Hodgkin lymphoma a few years ago and has had several recurrences. I was reading about something called chimeric antigen receptor-T cell therapy... Mayo Q&A: COVID-19 ...

Cartesian Therapeutics Shares Rise on Licensing Deal for WestGene Delivery Platform

Shares of Cartesian Therapeutics rose in premarket trading Tuesday after the company struck a deal to use WestGene Biopharma's lipid-nanoparticle delivery technology for its therapies for autoimmune ...