We have developed this method as an alternative to direct probe/target hybridization, which when used to study mutations in exon 11 of BRCA1 7, failed to detect the presence of the 1128insA mutation.

Figure 1: (A) Schematic of a fiber-optic DNA microarray. In this illustration microspheres functionalized with DNA sensing chemistry are randomly distributed on an optical imaging fiber surface. As ...

Comparative genomic hybridization (CGH) was developed to identify pathogenic DNA copy-number changes (e.g., duplications, deletions) on a genome-wide scale, and to map these changes to genomic ...