Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators.

Johannes holds an MSci in Neuroscience from King’s College London, where he worked on projects involving Alzheimer’s disease and Fragile X syndrome. Johannes holds an MSci in Neuroscience from King’s ...

While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

A phase 1 trial of JS001, a monoclonal antibody targeting programmed death-1 (PD-1) in patients with advanced or recurrent malignancies. This is an ASCO Meeting Abstract from the 2017 ASCO Annual ...

If they happen to do this just before the two DNA strands are cleaved as part of the cell replication process, the protons can become trapped on the wrong side, leading to a DNA mismatch and a ...

From the time we are conceived and through old age, genetic mutations accumulate in all our tissues, eluding the body’s typically efficient DNA repair machinery and potentially affecting our health ...

The topographical features of DNA in the body may dictate where and when cancer-causing mutations appear in its code. When you purchase through links on our site, we may earn an affiliate commission.

New research exploring theories of ageing has found that small mutations accumulating in DNA are unlikely to be fully responsible for this process. The research, a collaboration between the Wellcome ...