Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

Eukaryotic chromosomes replicate from multiple discrete loci termed origins of replication. These sites are first recognised by the origin recognition complex (ORC), which, together with Cdc6 and Cdt1 ...

Cdc7 kinase, in complex with its regulatory subunit Dbf4, orchestrates the initiation of eukaryotic DNA replication by phosphorylating components of the Mcm2–7 helicase complex at replication origins.

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...