The origin and early development of coronary vessels is unclear, although the textbook view is that they arise from the proepicardium — a transitory structure in the embryo that contacts and spreads ...

The human heart pumps between about 5 and 20 litres of blood through the body every minute 1. To receive enough oxygen to fulfil this tremendous task, heart-muscle cells need their own blood supply.

Taking advantage of genetic lineage tracing and tissue specific gene knockout technology, researchers found that part of liver vasculature is derived from endocardium in the developing heart. On March ...