Illustration of small molecule modulation of β-arrestins and GPCR signaling pathways based on concepts developed by the Lefkowitz Laboratory, Duke University. To function normally, nearly every cell ...

The study also clarifies the functional role of the receptor's conserved sodium-binding pocket, showing that sodium egress strongly promotes activation-related conformational states, including a ...

To function normally, nearly every cell in the human body relies on G-protein coupled receptors (GPCRs) to receive and send signals. That's why GPCRs are targeted by roughly one-third of all ...