Chronic hepatic inflammation and metabolic dysfunction characterize the pathology of nonalcoholic fatty liver disease (NAFLD). A new study published in Science Translational Medicine elucidates the ...
Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly influence the immune system, impacting both physiological and pathological processes. This review explores the ...
Interferon regulatory factor 3 (IRF3) is a key transcription factor in the type I interferon signaling. Its activation must be tightly controlled to efficiently activate innate immunity while avoiding ...
TLR4 recognizes bacterial-derived lipopolysaccharides and activates IRF3 via the adapter protein TRIF, contributing to the induction of type I IFN genes. Within endosomes, TLR3, TLR7, and TLR9 ...
Clues to the root cause of dysglycemia in obesity have now been uncovered by an international team of researchers, including scientists at the Dasman Diabetes Institute in Kuwait. “Most previous ...
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