Monthly Prescribing Reference

FDA: Risk of Inadvertent Intrathecal Administration of Tranexamic Acid Injection

Credit: FDA. The FDA has received reports of tranexamic acid injection being erroneously administered intrathecally in the perioperative setting instead of the intended intrathecal anesthetic (eg, ...
ascopubs.org

HIT: A multicenter phase I-II study of trastuzumab administered by intrathecal injection for leptomeningeal meningitis of HER2+ metastatic breast cancer.

ALTERNATIVE (EGF114299): A study of lapatinib, trastuzumab, and endocrine therapy in patients who received neo-/adjuvant trastuzumab (IV) and endocrine therapy. This is an ASCO Meeting Abstract from ...
Medscape

Signal of Benefit for Stem Cell Therapy in Progressive MS

West Palm Beach, Florida — In an interim analysis of an extension study, intrathecal injection of autologous bone marrow–derived mesenchymal stem cells (MSCs) has been associated with favorable ...
The American Journal of Managed Care

Nonadherence to Nusinersen Treatment Increases Health Care Utilization, Costs in SMA

Results of a retrospective claims database analysis suggest that adherence to scheduled intrathecal nusinersen injections may lead to improvements in comorbidities, health care utilization, and costs ...
The American Journal of Managed Care

The Impact of Intrathecal Onasemnogene Abeparvovec Therapy in SMA

Panelists discuss how intrathecal delivery of onasemnogene abeparvovec in the STEER study demonstrates statistically significant motor function improvements in older patients with SMA (ages 2-18 years ...