Cell migration is a multistep process essential to various physiological functions, including immune cell movement and embryonic development, as well as pathological conditions like tumor metastasis.

Metastatic disease—when cancer spreads from the primary tumor to other parts of the body—is the cause of most cancer deaths. While researchers understand how cancer cells escape the primary site to ...

Using a novel method that gives a readout of which proteins are in specific locations within cells, UT Southwestern Medical Center researchers have identified a protein that plays a key role in cell ...

Successful test in breast cancer patients: the active agent digoxin, a cardiac medication, dissolves clusters of circulating breast cancer cells in the blood, thus reducing the risk of metastases ...

Bone is a common site for metastasis of solid cancers, but histological and molecular features of bone metastases are not well understood. In a new study published in Cell Genomics, researchers at ...

Shi, Merghoub and colleagues show in the current study that distinct, functionally immature neutrophils associated with bone metastases produce another molecule, CHI3L3, that disrupts the activation ...

During embryonic development, the process of epithelial-mesenchymal transition (EMT) allows the migration of cells to different destinations to form organs and tissues. This same program is used by ...

Fluorescent image of of a patient’s colorectal cancer liver metastasis showing the diversity of cell states from normal intestinal states (dark blue) to atypical cell states (other colors). Image ...

The prestigious journal Hepatology Communications reports on the discovery by the Cancer and Translational Medicine research group of the University of the Basque Country (EHU). Tests on mice revealed ...

Bone is a common site for metastasis of solid cancers, but histological and molecular features of bone metastases are not well understood. In a new study published in Cell Genomics, researchers at ...