Investigators conducted a large retrospective study to determine whether high-dose methotrexate prophylaxis affected incidence of CNS relapse in patients with DLBCL at ultra-high risk for CNS relapse.

Rheumatoid arthritis (RA) is a chronic condition that occurs when the immune system attacks healthy joints. Doctors may treat the resulting inflammation and pain with methotrexate, a drug that ...

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Methotrexate injectable intravenous (IV) solution is only available as a generic drug. It doesn’t have a brand-name version. Methotrexate comes in four forms: injectable IV solution, self-injectable ...

LONG BEACH, Calif. -- Methotrexate, during and after surgery for primary retinal detachment, has produced "amazing" early results in preventing proliferative vitreoretinopathy (PVR), according to ...

Patients who take methotrexate for a variety of immune-mediated inflammatory diseases and pause taking the drug following receipt of a COVID-19 vaccine dose did not have a higher risk of disease flare ...

We compared the safety and efficacy of leflunomide with that of methotrexate in the treatment of polyarticular juvenile rheumatoid arthritis in a multinational, randomized, controlled trial. Patients ...

Uncontrolled gout can lead to arthritis in multiple joints due to too much serum acid, causing severe pain. (Horizon) More than a decade after Krystexxa's original approval, Horizon Therapeutics is ...

There have been a lot of questions about medical care and treatment in the wake of the overturning of Roe v. Wade, the landmark legislation that previously made abortion legal in the U.S. on a federal ...

Acute renal failure occurs in approximately 2% of patients who receive high-dose methotrexate for the treatment of a hematologic cancer. 1–3 Despite the frequency of acute renal failure and the ...

Since its approval in the late 1980s for the treatment of rheumatoid arthritis (RA), methotrexate has been the yardstick against which all other therapeutic agents against this disease, including the ...

Methotrexate is a primary disease-modifying anti-rheumatic drug (DMARD) used to treat rheumatoid arthritis (RA) by reducing inflammation and suppressing the immune system. The American College of ...