Progenitor cells that fulfil all the criteria defining the neural crest have not been observed outside vertebrates. These criteria include an embryonic origin at the lateral borders of the neural ...

Around the time of gastrulation in higher vertebrate embryos, inductive interactions direct cells to form central nervous system (neural plate) or sensory placodes. Grafts of different tissues into ...

Scientists have succeeded for the first time in directly reprogramming human blood cells into a previously unknown type of neural stem cell. These induced stem cells are similar to those that occur ...

The neural crest (NC) is a unique cell population associated with vertebrate evolution. For the first time, these multipotent cells were isolated from zebrafish embryos and maintained and ...

In Dr. Groves' lab, I am using transgenic mice to investigate the molecular mechanisms that specify multi-potent lineages at the neural plate border. This region is critical in vertebrates, harboring ...