The objective of this study is to characterize the relationship between forkhead box C2 protein (Foxc2) and leptin under adipose inflammatory response. In this study, we investigated the effects of ...
“Our study emphasizes the importance of distinguishing between STAT3α and STAT3β proteins and their active forms when discussing STAT3-related cancer diagnosis and therapy.” Signal transducer and ...
Serum carcinoembryonic antigen (CEA) levels and prognosis in early and advanced non-small cell lung cancer (NSCLC). Background: Evasion of cancer immunosurveillance (IS) is a hallmark of many ...
Figure 1: (A) Canonical STAT3 activation pathway. (B) WP1066 and TTI-101, examples of small molecule STAT3 inhibitors that are cell penetrant. Pediatric H3K27M-mutant diffuse midline gliomas (DMGs), ...
Recludix Pharma Inc. has divulged signal transducer and activator of transcription 3 (STAT3) and 6 (STAT6) inhibitors reported to be useful for the treatment of cancer and inflammation.
New research reveals how a cancer-associated protein enables tumor cells to evade the immune system by both suppressing anti-tumor influences and promoting tumor-enhancing conditions, in essence ...
Triple-negative breast cancer (TNBC) lacks hormone receptors and HER2 amplification, limiting the effectiveness of targeted therapies and contributing to its aggressive clinical behavior. As aberrant ...
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