Scientists discovered how macrophages, which act as the immune system's first line of defense, tailor their specific responses to various intruders through the independent and cooperative functions of ...
The FIPO23 trial: First-in-human phase I/II study of XON7 in advanced solids tumors. ATHENA: A phase 1/2 study of AZD5851, a chimeric antigen receptor (CAR) T-cell therapy directed against GPC3 in ...
The SWI/SNF protein complex was already known to carry out such changes, but it was unclear whether each of the three variants did so in a unique way or led to distinct macrophage behavior. To learn ...
SMARCA4 and SMARCA2 are essential subunits of the SWI/SNF complex, functioning as ATP-dependent chromatin remodelers that regulate gene expression and maintain cellular homeostasis. Recent research ...
In eukaryotic cells, nucleosomes—composed of histone octamers—address the topological challenge of DNA packaging by condensing the DNA within the nucleus., crucial for genetic information storage and ...
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How major nuclear protein complexes control specialized gene regulation in cancer and beyond
Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many human diseases, including cancers. However, how molecular machines—protein ...
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