The traditionally held hypothesis about the highly ordered organization of DNA describes the interaction of various proteins with DNA sequences to mediate the dynamic structure of the molecule.

Scientists have been unable to determine the structure of a biologically important so-called GAG proteoglycan -- or even to agree whether these remarkably complex molecules have well-defined ...

We describe a new computer program, Trilogy, for the automated discovery of sequence-structure patterns in proteins. Trilogy implements a pattern discovery algorithm that begins with an exhaustive ...

Although naturally occurring proteins form stable defined tertiary structures, it is well known that many proteins with non-natural sequences have unstructured conformations 1,2. This suggests that ...

When he wasn’t playing the viola or sailing around the Chesapeake Bay during the early 1950s, National Institutes of Health scientist Christian Anfinsen was hard at work in the lab trying to ...

A scientist has used a form of artificial intelligence known as deep learning to predict the 3D structure of effectively any protein based on its amino acid sequence. This new approach for ...