Zinc finger nucleases are designed to be like heat-seeking missiles, precisely targeted to find and cut specific sequences of DNA. Occasionally, however, they may snip the wrong spot, causing ...

The left-handed spiral of each Z-DNA strand is highlighted on the left. Binding and bonding of the two zinc finger domains (shown in red) from the CTCF protein to Z-DNA (shown in blue). This protein ...

RNA-binding proteins use a dual binding mechanism involving zinc finger (ZnF) domains and intrinsically disordered regions (IDR), reports a new study from Institute of Science Tokyo, Japan. Using ...

Researchers have, for the first time, modified a single, disease-causing mutation without altering any other parts of the genome in human stem cells. Scientists in Rudolph Jaenisch’s lab at the ...

Sangamo Therapeutics Inc. and Chroma Medicine Inc. have entered into a research evaluation, option and license agreement to develop epigenetic medicines leveraging zinc finger proteins (ZFPs) for ...