Drug classes such as alpha-1 blockers, atypical antipsychotics, and tricyclic antidepressants were associated with an increased incidence of intraoperative floppy iris syndrome (IFIS), with imipramine ...

Credit: Getty Images In an unexpected finding, phosphodiesterase inhibitors and sympathomimetics with α- and β-effect were strongly associated with higher AKI risk in this analysis. High AKI risk was ...

Individuals with HIV who were resistant to all four antiretroviral drug classes experienced higher mortality than those who were not resistant, a difference primarily due to lower CD4 cell counts.

Researchers looked specifically at head-to-head randomized clinical trials of next-in-class cancer drugs against existing agents in the same class. Less than one-quarter of next-in-class cancer drugs ...

Editor's note: This is an automatically generated transcript. Please notify editor@healio.com if there are concerns regarding accuracy of the transcription. If you look at the last 20 years as a ...

Please provide your email address to receive an email when new articles are posted on . The thiazolidinedione pioglitazone and GLP-1 receptor agonists are the only two diabetes drugs proved to ...

First-in-class drugs can be highly innovative because of their novel mechanisms of action, but they also carry uncertainty in the absence of clinical experience. To understand how such drugs advance ...

How the 8 Approved Medications Compare ...

The choice of which therapeutic alternatives to compare drugs against will be foundational in Medicare’s drug price negotiation, now and in future years. We believe a broad approach to the selection ...