DNA methylation is a key epigenome component that helps dictate how genes are expressed, contributing to normal cell and tissue differentiation during development, as well as the process of biological ...

Heterozygous loss in gene encoding methyl-CpG binding protein Zbtb38 leads to early embryonic death via the suppression of transcription factors Nanog and Sox2 Ikoma, Japan—DNA methylation is a major ...

DNA and RNA methylation, initially thought to operate as distinct pathways, have been shown to interact closely, shifting our understanding of gene regulation. A team of researchers from the ...

The study covered in this summary was published in medRxiv as a preprint and has not yet been peer reviewed. Previous attempts to identify causal associations between DNA methylation and both obesity ...

Plants make use of distinct types of DNA methylation characterized by their DNA methyltransferases and modes of regulation. One type, RNA-directed DNA methylation (RdDM), is guided by small ...

As mice are a vital model organism and DNA methylation is commonly used in epigenetic studies, researchers have developed a high-throughput genomic array for DNA methylation for a more detailed view ...

DNA methylation is a fundamental epigenetic mechanism in which a methyl group is added onto a nucleotide, commonly cytosine. DNA methylation affects many biological processes, including gene ...

In a recent study published in the journal Molecular Psychiatry, a team of researchers conducted a large-scale meta-analysis consisting of an epigenome-wide association study to understand whether ...

Amyotrophic lateral sclerosis (ALS) is an intractable neurological disease. Aging is a risk factor for the accumulation of TDP-43 (transduction responsive region DNA-binding protein of 43kDa) in the ...

Researchers have found that heterozygous loss of the methyl-CpG binding protein Zbtb38 downregulated the expression of the transcription factors Nanog and Sox2, as well as genes involved in epiblast ...