Loss of Pericytes Wreaks Havoc in Mouse Brain - ALZFORUM
Feb 10, 2018 · Loss of pericytes, delicate cells that surround the smallest blood vessels in the brain, may contribute to white-matter disease, a breakdown of the myelinated neurons in the …
Amyloid β oligomers constrict human capillaries in ... - ALZFORUM
Jun 22, 2019 · Second, it identifies capillary mural cells, such as pericytes, as critical for the capillary constriction. Third, it suggests that in these cells NOX4, rather than NOX2, is the …
Reconstruction of the human blood-brain barrier in vitro reveals a ...
Jun 29, 2020 · The Tsai lab examined vascular amyloid deposition with a three-dimensional model of the blood-brain barrier using endothelial cells, mural cells (pericytes and vascular …
ALZFORUM | NETWORKING FOR A CURE
Jun 21, 2019 · Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, O'Farrell FM, Buchan AM, Lauritzen M, Attwell D. Capillary pericytes regulate cerebral blood flow in …
Pericytes Don’t Go With the Flow—They Change It - ALZFORUM
Feb 13, 2017 · Pericytes shrink and die in patients with Alzheimer’s disease, and the study supports the idea that the loss of these cells promotes the disease’s pathology. “It makes a …
Evidence that tunnelling nanotube-like structures connect
Aug 19, 2020 · Bridging pericytes are described in the recent preprint by Hartmann et al., who reported that ablation of bridging pericytes dilate both the proximal and distal capillaries, which …
APPsw/0; Pdgfrβ+/- - ALZFORUM
May 2, 2014 · Pericyte proliferation, migration, and recruitment to the vascular wall is regulated by the growth factor PDGFβ, and therefore, genetic disruption of the PDGFβ receptor gene …
Mutations Database | ALZFORUM
This database is a repository of variants in genes implicated in Alzheimer’s disease (AD). Currently, it includes the three genes associated with autosomal-dominant AD (APP, PSEN1, …
Finally, a Dye to Visualize Pericyte Function - ALZFORUM
May 23, 2017 · Pericytes—dainty little cells that decorate the brain’s smallest blood vessels— are drawing growing research interest, and controversy. For one, whether these cells help control …
Pericytes and perivascular fibroblasts are the primary source of ...
Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol. 2008 Dec;173 (6):1617-27.